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Animal and Food Sciences | Faculty

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Larry A. Cogburn, Ph.D.


Education
  • Poultry Science, University of Illinois, Urbana-Champaign, Ph.D. 1978
  • Environmental Physiology, North Carolina State University, Raleigh, M.Sc., 1974
  • Physiology, North Carolina State University, Raleigh, B.S., 1972

Current Courses

  • ANSC 445, Comparative Physiology of Domestic Animals
  • UNIV 401/402; Research Advisor and Sponsor, Degree with Distinction and Honors Degree with Distinction
Recent Federal Grants
  • USDA-NRI Grant 2005-35206-15288.  Integrated Analysis of Gene Networks Controlling Feed Intake and Energy Metabolism in Chickens. L.A. Cogburn and T.E. Porter, Co-PD
  • USDA-IFAFS Grant 00-52100-9614: A Consortium for Functional Mapping of Growth-Regulating Genes in Broiler Chickens.  L.A. Cogburn (PD), T.E. Porter, J. Simon, and S.E. Aggrey, Co-PIs

Research Interests 

  • Endocrine Regulation of Avian Growth and Metabolism
  • Avian Functional Genomics
  • Gene Network Modeling
  • Development of Molecular Markers for Genetic Selection
  • Molecular and Genetic Mechanism of Obesity and Type II Diabetes
  • Comparative and Evolutionary Genomics
  • Integrative Genomics
  • Avian Systems Biology
Patents
  • Cogburn, L. A., Molecular Markers for Identification of Fat and Lean Phenotypes in Chickens, U.S. Patent Application, Serial No. 60/359,846 filed February 27, 2003. [Pub. No.: US 2003/0186299 A1; Pub. Date: Oct. 2, 2003]
  • Cogburn, L. A., Molecular Markers for Identification of Fat and Lean Phenotypes in Chickens, U.S. Patent Application, Serial No. 11/013,536 filed December 12, 2003. [Pub. No.: US 2005/0214814 A1; Pub. Date: Sep. 29, 2005]
Professional Activities
  • The Endocrine Society
  • American Physiological Society
  • Poultry Science Association
  • Sigma Xi
  • American Association of University Professors

Recent Publications

Ankra-Badu, G. A.,  D. Shriner, E. Le Bihan-Duval, S. Mignon-Grasteau, F. Pitel, C. Beaumont, M.J. Duclos, J. Simon, T.E. Porter, A. Vignal, L. A. Cogburn, D. B. Allison, N. Yi and S. E. Aggrey, 2010. Mapping main, epistatic and sex-specific QTL for body composition in a chicken population divergently selected for low or high growth rate. BMC Genomics (accepted)

Higgins, S.E., L.E. Ellestad, N. Trakooljul, L.A. Cogburn, F. McCarthy, J. Saliba and T.E. Porter, 2009. Global gene expression and pathway analysis in the hypothalamus of neonatal chicks during feeding, fasting and delayed feeding. BMC Genomics (accepted)

Ankra-Badu, G.A., Le Bihan-Duval, E., Mignon-Grasteau, S., Pitel, F., Beaumont, C., Duclos, M.J., Simon, J., Carre, W., Porter, T.E., Vignal, A., Cogburn, L.A, Aggrey, S.E., 2009. Mapping quantitative trait loci for growth and shank traits in chickens divergently selected for high or low body weight.  Animal Genetics (in press)

Jonchere, V., S. Réhault-Godbert, C. Hennequet-Antier, C. Cabau, V. Sibut, L. A. Cogburn, Y. Nys  and J. Gautron, 2010. Gene expression profiling to identify eggshell proteins involved in physical defense of the chicken egg. BMC Genomics 11:57.

Wang,  X., R.F. Newkirk, W. Carre, P. Ghose, B. Igobudia, J. G. Townsel  and L. A. Cogburn, 2009. Regulation of ANKRD9 expression by lipid metabolic perturbations.  BMB Reports 42:568-573.

Nadaf, J., F. Pitel, H. Gilbert, M.J. Duclos, F Vignoles, C. Beaumont, A. Vignal, S. E. Aggrey, T.E. Porter, L.A. Cogburn, J. Simon and E. Le Bihan-Duval, 2009. QTL for several metabolic traits map to loci controlling growth and body composition in a F2 intercross between high-growth and low-growth chicken lines. Physiological Genomics (38:241-249).

Le Mignon, G., F. Pitel, H. Gilbert, E. Le Bihan-Duval, F. Vignoles, O. Demeure,

S. Lagarrigue, J. Simon, L. A. Cogburn, S. E. Aggrey, M. Douaire and P. Le Roy, 2009. A comprehensive analysis of QTL for abdominal fat and breast muscle weights on chicken chromosome 5 using a multivariate approach.  Animal Genetics 40:157-164.

Byerly, M. S., J. Simon, E. Lebihan-Duval, M. J. Duclos, L A. Cogburn and T. E. Porter, 2009. Effects of BDNF, T3 and corticosterone on expression of the hypothalamic obesity gene network in vivo and in vitro. AJP-Regulatory, Integrative and Comparative Physiology 296:R1180-1189.

Dupont J, Tesseraud S, Derouet M, Collin A, Rideau N, Crochet S, Godet E, Cailleau-Audouin E, Metayer-Coustard S, Duclos MJ, Gespach C, Porter TE, Cogburn LA, and Simon J, 2008. Insulin immuno-neutralization in chicken: effects on insulin signaling and gene expression in liver and muscle. J Endocrnol 2008, 197:531-542.

Cogburn, L. A., T. E. Porter, M.J. Duclos, J. Simon, S. C.Burgess, J.J. Zhu, H.H. Cheng, J. B. Dodgson and J. Burnside, 2007. Functional genomics of the chicken—a model organism. Poultry Sci. 86:2059-2094

Nadaf, J., H. Gilbert, F. Pitel, C. Beaumont, C. M. Berri, M. J. Duclos, T.E. Porter, J. Simon, S. E. Aggrey, L. A. Cogburn, E. Le Bihan-Duval, 2007. Identification of QTL controlling several meat parameters in a F2 cross between two chicken lines selected for either low or high growth. BMC Genomics 8:155.

Wang, X., W. Carré, A. M. Saxton and Cogburn, L.A., 2007. Manipulation of thyroid status and/or GH Injection alters hepatic gene expression in the juvenile chicken. Cytogenet. Genome Res. 117:174-188.

Dichlberger, A., L. A. Cogburn, J. Nimpf, and W. J. Schneider. 2007. Avian apolipoprotein A-V binds to LDL receptor gene family members. J. Lipid Res. 48:1451-1456.

Walzem, R. L., R. A. Baillie, M. Wiest, R. Davis, S. M. Watkins, J. Simon, T. E. Porter, and L. A. Cogburn. 2007. Functional annotation of genomic data with metabolic inference. Poult. Sci. 86:1510-1522.

Carre, W., X. Wang, T. E. Porter, Y. Nys, J-S Tang, E. Bernberg, R. Morgan , J. Burnside, S.E. Aggrey, J. Simon, and Cogburn, L. A., 2006. Chicken functional genomics resource: sequencing and annotation of 35,407 ESTs from single and multiple tissue cDNA libraries and CAP3 assembly of a chicken gene index. Physiol. Genomics 25:514-524

Ellestad, L.E., W Carre, M. Muchow, S.A. Jenkin, X. Wang, L.A. Cogburn, and T.E. Porter, 2006. Gene expression profiling during cellular differentiation in the embryonic pituitary gland using cDNA microarrays. Physiol Genomics 25:414-425

Lagarrigue, S., F. Pitel, W. Carré, B. Abasht, P. Le Roy, A. Neau, Y. Amigues, M. Sourdioux, J. Simon, L.A. Cogburn, S. Aggrey, B. Leclerq, A. Vignal and M. Douaire, 2006. Mapping of quantitative trait loci affecting fatness and breast muscle weight in experimental meat-type chicken lines divergently selected on fatness Genet. Select. Evol. 38: 85-97

Abasht, B., Pitel, F., Lagarrigue, S., Le Bihan-Duval, E., Le Roy, P., Demeure, O., Simon J., Cogburn, L. A., Aggrey, S.E., Vignal, A. and Douaire, M. 2005. Fatness QTL on chicken chromosome 5 and interaction with sex. Genet. Select. Evol. 38:297-311

Wang, X., W. Carre, L. Rejto and L.A Cogburn, 2005. Chapter 3. Transcriptional Profiling in Liver of Hormonally-manipulated Chickens. In: Functional Avian Endocrinology (A Dawson & PJ Sharp, Eds) Narosa Publishing House, New Delhi, India, pp 27-44

Burnside, J. L.A. Cogburn, R. Talbot and J.B. Dodgson. 2005. Chapter 1. Genomic Tools for Endocrine Research. In: Functional Avian Endocrinology (A Dawson & PJ Sharp, Eds), Narosa Publishing House, New Delhi, India, pp 3-10.

Pending Publications

Le Bihan-Duval, E., J. Nadaf, C. Berri, F. Pitel, E. Godet, S.Y. Leroux, O. Demeure, S. Lagarrigue, C. Duby, L.A. Cogburn, J. Simon, C.M. Beaumont, and M.J. Duclos, 2010.  Two linked single nucleotide polymorphisms in the promoter of β-carotene 15, 15'-monooxygenase (BMCO1) are responsible for variation in breast meat color of the chicken. (submitted)

Trakooljul, N., W. Carré, X. Wang, E. LeBihan-Duval, M. Duclos, J. Simon, T.E. Porter,     L.A. Cogburn, 2009. Transcriptional analysis of the liver during juvenile development in chickens divergently selected for high or low body weight. (submitted)

Cogburn, L. A., T. E. Porter, N. Trakooljul, X. Wang, W Carré, A Gandhi, M. S. Byerly, L. E. Ellestad, M. Muchow, S. Jenkins, F. McCarthy, S. Bridges, S. Burgess, A. Saxton, and J. Simon, 2009. Utility of the Del-Mar 14K chicken integrated systems microarray for transcriptional profiling in avian tissues. (submitted)
More publications [ + ]

Cogburn, L.A., Sofer L. and J. Burnside, 1997. Molecular cloning and sequence analysis of chicken type I deiodinase cDNA: Expression in normal and dwarf broiler chickens. Biochem. Biophys.Res.Comm. 241:459-464.

Cogburn, L.A., J.N.C. Mao and J. Burnside. 1997. The Growth Horomone Receptor in Growth and Development. In: Perspectives in Avian Endocrinology (S. Harvey and R. Etches, eds.), J. of Endocrinology Press, Bristol, UK, pp. 101-116.

Burnside, J., S.K. Agarwal and L.A. Cogburn, 1997. Intracellular Mechanism of Growth Horomone Signaling. In: Perspectives in Avian Endocrinology. (S. Harvey and R. Etches, eds.), J. of Endocrinology Press, Bristol, UK, pp.359-373.

Mao, J.N.C., L.A. Cogburn and J. Burnside, 1997. Growth Horomone (GH) down- regulates GH receptor (GHR) mRNA in chickens but developmental increases in GHR mRNA occur independently of GH action. Mol. Cell. Endocrinol. 129:135-143.

Harvey, S. and L.A. Cogburn, 1996. Cryptic peptides of prepro-TRH antagonize TRH- induced GH secretions in chickens at extrapituitary sites. J. Endocrinol. 151:359-364.

McMutry, J.P., W. Tsark, L. Cogburn, R. Rosebrough, and D. Brocht, 1996. Metabolic responses of the turkey hen (Meleagris gallopavo) to an intravenous injection of chicken or porcine glucagon. Comp. Biochem. Physiol. 114C:159-163.